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PRINCIPAL INVESTIGATORS

Michael V. Sefton, PhD
University Professor
Michael E. Charles Professor of Chemical Engineering

Member of the United States Institute of Medicine (IOM)

Department of Chemical Engineering and Applied Chemistry
Institute of Biomaterials and Biomedical Engineering (IBBME)
Donnelly Centre for Cellular + Biomolecular Research
University of Toronto

Hospital Affiliation: Sunnybrook Health Sciences Centre, UHN  

Education:
Massachusetts Institute of Technology
ScD in Chemical Engineering, 1974

University of Toronto
BSc in Chemical Engineering and Applied Chemistry, 1971

   

My Story:

It is not science fiction to say that one day, patients will have access to lab-grown body parts. In fact, that is my lab’s ultimate goal—to be able to grow completely functioning human organs. We practise tissue engineering and regenerative medicine, and are interested in the effect of biomaterials on biological responses. We are especially interested in inflammation, tissue remodeling and new blood vessel development (angiogenesis).    

Thanks to my lab’s pioneering work in tissue engineering, my team has been among the first to explore the mixing of cells and materials, now with a view to create new tissue structures ranging from an artificial pancreas to cardiac patches. The materials and strategies we explore are being studied for their utility in a range of medical devices ranging from drug eluting stents to wound dressings. The results of some of this work are already available to patients.

As part of the Donnelly Centre, it will be possible to adapt high throughput biological methodologies to discover new materials, or new targets for existing materials. Collaboration is a very effective way to explore novel concepts and materials. Working in the Donnelly Centre is useful to push the frontier further back into the basics of biological interactions.

For more information on my work, please e-mail me at michael.sefton@utoronto.ca

 

 

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